Lopez : 1: Spanish (López): patronymic from the medieval personal name Lope ‘wolf’. This is one of the commonest of all Spanish surnames. In the US it is the twelfth most frequent surname. Compare De Lopez.2: Jewish (Sephardic): adoption of the Spanish surname (see 1 above) at the moment of conversion to Roman Catholicism. After the return to Judaism (generations later) some descendants retained the name their families used as Catholics.
Source : DAFN2 : Dictionary of American Family Names 2nd edition, ©2022 by Patrick Hanks and Oxford University Press
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